I think the Colts offense is in trouble without T.Y. Hilton. Indy is 0-5 without Hilton since he entered the league in 2012 (the last game Hilton missed, Colts pass-catchers had five drops in a Week 4 loss to the Raiders). Pittsburgh's defense is ninth overall. The Colts always struggled playing in Pittsburgh and it will be chilly at kickoff.
Look for the 2nd half momentum to carry over from MNF and the Steelers to grab a win here at home.