This will be the undefeated 6-0 San Francisco 49ers biggest test of the season, and I think the surging 4-2 Carolina Panthers will give the Niners a real scare here.

The Panthers will enter this contest with a ton of confidence after reeling off four straight wins following an 0-2 start. They'll be fresh and well prepared coming off their bye while the Niners picked up an ugly 9-0 win on a soggy, muddy field at Washington last week. The Niners defense spent most of its time stopping the run, and now they'll be faced with the task of slowing down one of the most dominant running backs in the game in Christian McCaffrey.

Panthers are 6-1 ATS vs. a team with a winning record. 49ers are 2-5 ATS vs. a team with a winning record. Panthers are 9-1 ATS in their last 10 meetings in San Francisco.

8* play on Carolina Panthers.