Stephen Nover's NFL Bookie Buster - 13-7-2 NFL Hot Streak
(NFL) Arizona vs. LA Rams,
Point Spread: 3.00 | -112.00 LA Rams (Home)
Result: Win
Sean McVay may have picked up a few critics since the Rams' Super Bowl loss to the Patriots two seasons ago. I'm not one of them. The Rams have a far better defense than the Cardinals and McVay had an entire week to prepare fill-in QB John Wolford and devise a suitable game plan. 
Losing Jared Goff is a negative. Goff, though, isn't an elite quarterback. He's slightly above average - and that's with a clean pocket and being in a warm-weather site. The Rams lose experience and downfield passing with the drop from Goff to Wolford. But they gain far more quarterback mobility. McVay is one of the top play-callers in the NFL. I'm confident he will put Wolford in a position to succeed. 
The Rams won't have their top wide receiver Cooper Kupp, or probably two of their three best running backs. They still provide plenty of receiving weapons for Wolford with Robert Woods, Josh Reynolds, underrated rookie Van Jefferson and one of the better tight end duos in the NFL, Tyler Higbee and Gerald Everett. 
The Cardinals have sprung a leak with their run defense due in part to injuries. 49ers backup running back Jeff Wilson rushed for 183 yards against them last week. Arizona has permitted 5.2 yards per run during the past four games. Effective running by the Rams can set up Wolford. 
At best, the Cardinals' defense is mediocre. They rank 15th in scoring defense. LA's defense could be the best in the NFL ranking first in total yards and pass defense while giving up the third-fewest points at 19.3 per game. 
Kyler Murray needs to run and roam free for the Cardinals to have success. Murray is hampered by a lower-body injury. He also has to deal with the monstrous Aaron Donald, the NFC's sack leader with 13 1/2. Murry relies on the magnificent DeAndre Hopkins. However, Hopkins isn't 100 percent either and he has his own defensive demon to content with - shutdown cornerback Jalen Ramsey. 
So the outstanding Rams defense is well equipped to deal with the Cardinals' offensive strengths. Murry is 0-3 lifetime against the Rams, who have held him to a 57 percent completion rate, 5.8 YPA, a 5-to-4 touchdown-to-interception ratio and only an average of 14 yards rushing per game. 
McVay has never lost to the Cardinals posting a 7-0 SU, 6-0-1 ATS record versus Arizona. The Rams have beaten the Cardinals by an average of three touchdowns. 
The Rams wouldn't need to win this game to earn a playoff spot if the Bears lose to the Packers. However, that game starts the same time as this matchup so the Rams will be assured of having their full focus and going all out.