Betting Trend: Road favorites with a winning percentage of 75% or more are 121-158 ATS (43%) in the past decade.

The Bills have a few noteworthy injuries, including WRs Keon Coleman and Amari Cooper. The Colts' run defense is trending up, so a run-heavy approach would work in their favor. Buffalo has played several close games recently and with the Chiefs on deck, could be caught looking ahead.

Joe Flacco and the Indy offense will look much better again this week now that they're not facing Minnesota's blitz-centric scheme. He has been a considerable upgrade to Anthony Richardson, and with RB Jonathan Taylor back and more game-ready, the Indianapolis offense should move the chains.

This is a game Indy must play well in, and I believe it will. Take the Colts +4 down to +3.5.