This is an 8* BLOWOUT PLAY on the SAN FRANCISCO 49ERS.

Buffalo is 8-3 overall, including 3-2 on the road. Straight-up. It's just 2-3 ATS away from friendly confines.

Normally home field is a big advantage for the 49ers, but that's not been the case this season, going just 1-4 SU/ATS so far. But that lop-sided number gets corrected here in my opinion.

The 49ers won a crucial game over the Rams last time out and they now have an opportunity to chase down Arizona in the division with the Cards' loss to LA on Sunday.

The 49ers' defense remains its strength and I think Josh Allen will have difficulty throwing against this opportunistic 49ers secondary.

The Bills have been terrible defensively this year, which is good news for Nick Mullens and the hungrier home side.

For all the reasons listed above, play on San Francisco!

Good luck, NP