Buffalo doesn't defend the run particularly well, and Jonathan Taylor has 100+ scrimmage yards in four of the last five games. The Colts have a good offensive line, they will run the ball, and they will have a chance to control the clock. The Colts are tied for the most takeaways in the AFC.

The Colts looked awful on the road Sunday Night Football against Minnesota, but their largest home loss of the season came by exactly two points; a team built to win in the home dome. The Colts have now played 10 straight games dating back to last year that have been decided by a single score so we are taking the points with INDY.