The 49ers are on fire this season, averaging an impressive 25.8 points per game while limiting opponents to just 20.5, showcasing their dominant defense. They rank second in the NFL with 413 total yards per game and ninth in yards allowed at only 295.3, highlighting their balance.

The Cardinals have a dismal 2-5 ATS record in divisional matchups since 2023. Their failure to cover the spread in their last two games against the Lions and Commanders only underscores their ineptitude ATS. SF 49ers win in a blowout on Sunday evening!