The Saints have a good defense and the Cowboys have played the 3 worst defenses in the NFL in the NYG, Redskins, and Miami Dolphins.
I don't think Dak Prescott will do great with the road crowd in the dome and the Saints defensive front will pressure him, which gives New Orleans a big edge.
Even without Drew Brees, I like the Saints with an extra week of practice for Teddy Bridgewater and his receivers and Taysom Hill should see some action at QB as well. I like the Saints on Sunday night football at home.