Jacoby Brissett looked good last week and the offensive line is one of the best. The Titans looked great in Week 1, partly because they were able to rough up the Browns' O-line, but that won't happen against the Colts. Tennessee took advantage of two Browns weaknesses (OL and run defense) that are Colts strengths, and Indy has always had the Titans' number (12-2 vs. Tennessee since 2012). Jacoby Brissett and the Colts get the win here on the road and even up their record Sunday afternoon as your comp.