It would certainly appear as thought there's a first-string advantage here with the Buffalo Bills. Indications are the Bills are going to play the first unit offense and defense for at least the first quarter, perhaps even a series in the second quarter. McDermott did that last season in a Week 2 and it sounds like he's going to repeat that process here. N
QB's will be Josh Allen, Matt Barkley and Tyree Jackson which I like over the 3 man QB rotation for the Panthers as Cam Newton is OUT.

Major edge with the Buffalo first team playing here on Friday night.