Buffalo vs San Francisco (at Glendale, AZ)
49ers over Bills- As most are aware this game has been shifted to Arizona as COVID has forced the move from California. Buffalo has won four of five with the lone loss coming on this field against the Cardinals when a 'Hail-Mary' pass handed them their only defeat. The Bills who were the same 8-3 a year ago went 2-3 their final five games while many have to be reminded that the 49ers were in the Super Bowl last season. SF is getting healthy as players return and the Bills face the undefeated (as of now) Steelers next week. That SAN FRANCISCO!