Jacksonville at San Francisco 4:05 ET
49ers (+) over Jaguars- Boy, do 'we' love that Jaguars defense! Jacksonville defense is ranked No. 1 in scoring defense, sacks, passing yards forced fumbles and third in total yards and yet they have something in common with San Francisco...they have both won their last three games. Jimmy Garoppolo is undefeated as a 49ers starter (3-0) but will be facing a stone wall Sunday. The Jaguars are little banged-up with Fournette and Allen missing practice time this week. Niners have enough defense to neutralize Blake Bortles inconsistent play. Take SAN FRANCISCO!