San Diego left-hander Sean Manaea (3-3, 3.52 ERA) has allowed only three runs (two earned) on eight hits while striking out 11 in two starts covering 13 innings this month.

Manaea has a 3.03 ERA in six road starts this season and the Cubs are averaging only 3.78 runs per nine innings off southpaws.

The Cubs are coming into this game on a seven-game losing streak after dropping the opener of this series 4-1 on Monday. Cubs righty Kyle Hendricks (2-5, 5.22 ERA) is 0-2 with an 8.04 ERA in his past three starts home at Wrigley Field.

Padres are 10-3 in their last 13 games as a road favorite. Cubs are 5-12 as home underdogs in 2022.

Free pick on San Diego Padres.

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