Both reams could have their playoff positions locked in by the time the game kicks off. There is a chance that starters will be rested, which makes taking the points all the more attractive IMO. Also, the San Francisco 49ers match up very well against the Rams. They are 4-1 ATS in their last 5 meetings and defeated the Rams 31-10 in the first game of the season.

49ers are 4-1 ATS in their last 5 games as an underdog. Rams are 5-12-1 ATS in their last 18 home games vs. a team with a winning road record.

8* play on San Francisco 49ers.