Twice these teams have met this season. The results were similar. Cal-Irvine won 68-49 on Jan. 22 and beat Cal Poly-SLO again, 67-44, on Jan. 23. The margins of those victories was 19 and 23 points, respectively.
I'm not anticipating anything closer this time around either. 
Cal Poly surprised Cal-State Fullerton, 87-82, two days ago in the opening of this Big West Conference Tournament. The Titans were rusty having played just twice following a COVID-19 pause. Still, Cal-Poly scoring that many points was an outlier. The Mustangs are one of the worst teams in the nation. Even with that victory, they are 2-17 in their last 19 games. The Mustangs entered that matchup averaging 59.5 points in their previous five games while ranked 342nd in scoring and 335th in field goal percentage. 
Cal Irvine isn't going to take Cal Poly lightly now after seeing what the Mustangs did to Cal-State Fullerton. Unlike the Titans, the Anteaters enter tournament play on the upswing winning six of their last seven, including a 15-point road win against Long Beach State in their last game five days ago. 
The Anteaters rank 29th defensively giving up 63.4 points per game. They are seventh in the nation in defensive field goal percentage. Cal-Poly won't be able to handle that strong of a defense just like in the first two games between the teams.