COVID-19 has been a definite handicapping factor this college basketball season. It certainly factors in this matchup and is a major reason why I like home 'dog Quinnipiac. 
Iona just returned from a COVID layoff of close to two months playing two home games against Manhattan this past Friday and Saturday. The Gaels were favored in both of those matchups and ended up splitting the two games. It was their first action since Dec. 23. No other school had gone longer between games this season. 
Now Iona plays a road game for the first time since Dec. 19. I don't think all of the rust is off yet, not to mention so many missed practices. 
This will be Quinnipiac's fifth game in 11 days. The Bobcats are in stop-the-pain mode with three straight losses. Quinnipiac is ranked 172nd defensively in the KenPom adjusted defensive rankings. The Bobcats have the seventh-best defensive field goal percentage in the nation. Iona is ranked 247th in the KenPom adjusted defensive ratings. 
The underdog is 5-1-1 ATS the past seven times in the series. So I'll take the points with the better defensive team in the better situation.