The Cardinals beat the 49ers, 24-20, back in Week 1 when San Francisco was healthy. Now the 49ers are decimated by injuries and demoralized following a 41-33 loss to the Cowboys last week that eliminated them from playoff contention one season after reaching the Super Bowl. 
Oh, yes, San Francisco is down to third-string QB C.J. Beathard. Care to know the 49ers' record in Beathard's previous 15 appearances, including 11 starts? It's 1-14. 
The 49ers are well-coached, but they can't overcome probably the highest and most significant injury list in the league. The 49ers have committed multiple turnovers in eight consecutive games due to sloppy quarterback play. 
San Francisco is 1-6 SU and ATS in its last seven games. All of the defeats have been by at least eight points. It's obvious the 49ers are out of fuel at this late stage.
Not so for the 8-6 Cardinals who are battling for a playoff spot. They rank third in the NFL in yards per game and are 13th in total defense. Sparked by Kyler Murray, the Cardinals have produced 30 or more points in six of their last 10 games.