The Raiders are the only team that can claim victories against the Chiefs and Saints. But Las Vegas also is capable of losing to any team. The Raiders needed a late long TD pass to nip the winless Jets last week and two weeks ago were blown out by the 4-8 Falcons, 43-6. 
Derek Carr is the Raiders' focal point if Josh Jacobs remains out with an ankle injury. Carr is having a good season, but I would take the Colts defense over him. The Colts give up the fifth-fewest yards, the third-fewest TD passes and have the fourth-best defensive passer rating. 
Philip Rivers is not a mobile QB and the Colts have offensive line injuries. But the Raiders are tied for the third-fewest sacks in the NFL with 15. The Raiders are well below average in all of the major defensive categories, including ranking 28th in scoring defense allowing 28.9 points per game. This figure would be even higher if the Raiders didn't hold the Browns to six points in a game heavily impacted by bad weather and gusting winds. 
I see the Colts as a well-coached, professional team with a good defense that rarely beats itself. The Raiders can't make that claim. They are too undisciplined and inconsistent.