The records show 5-1 and 3-4. But it's the Bills who are the 5-1 team. Buffalo has a very solid defense. The Bills' offense scares no one, though. Buffalo has built its record by beating the Jets, Giants, Bengals, Titans and Dolphins. Combined record of those teams is 6-27. None of those foes is above .500. 
The Eagles opened 3-2 before losing consecutive road games to the Vikings and Cowboys. Philly was outmatched in those games. The Eagles won't be here. They also won't lack motivation after a humiliating national TV loss to the Cowboys unlike the Bills, who are fat and happy. 
Buffalo is heavily run-oriented. Bills second-year QB Josh Allen is turnover-prone. The Eagles have gotten healthier in the secondary and rank seventh in rush defense. They've been tough on every running back except superstar Ezekiel Elliott.