Burying the Ravens on the road last Sunday was huge for the Browns. Both from a confidence standpoint and also to reinforce their high talent level. Cleveland achieved that victory despite missing its starting cornerbacks, Denzel Ward and Greedy Williams. Both could return here.
The 49ers can't match the Browns' skill position talent of Bakery Mayfield, Odell Beckham Jr., Jarvis Landry and Nick Chubb. Cleveland's offensive line has been a weak spot. But the 49ers are minus their top offensive lineman with left tackle Joe Staley out with a leg injury. Myles Garrett, who is in the argument for being the best pass rusher in the AFC, could be in line for a huge game. 
The 49ers are just 7-17 ATS in their last 24 home games since making the move to Levi's Stadium in Santa Clara. They haven't covered as home chalk in five years. 
I respect Kyle Shanahan. I think the 49ers are much improved. But they are not a playoff contender. Cleveland is. The Browns are the superior team catching points. The 49ers have a weak home field. So getting points is a nice bonus.