Kansas is going to take TCU's best punch after the Horned Frogs suffered a humbling 41-38 loss to city rival SMU last weekend. TCU was 7 1/2-point favorites in that game. The loss knocked them out of the Top-25. 
Gary Patterson is a no nonsense coach. He's not going to screw around here. The Horned Frogs are going to pound away at Kansas, which could be missing its leading tackler, linebacker Dru Prox. Patterson will be reminding his squad about last season's game when the Jayhawks upset the Horned Frogs, 27-26, in Kansas. 
The Jayhawks are improved under new coach Les Miles. They have some good skill position players particularly at running back. But TCU owns the defensive edge and has a strong advantage in the trenches. 
This probably isn't going to be a pretty win, but in the end I see the Horned Frogs controlling clock and winning by more than two touchdowns.