With just a one-point overtime victory against Louisiana Monroe, Florida State is desperate for a victory. The Seminoles are 1-2, but could be 3-0 having blown fourth-quarter leads against Virginia and Boise State. 
Florida State has the athletes and talent especially on offense. James Blackman has come through at quarterback and Cam Akers is one of the best running backs in the country.
Scott Satterfield is doing a good job in his first season at Louisville. But he has a major rebuild job to do. The Cardinals are coming off easy wins against two overmatched opponents, Eastern Kentucky and Western Kentucky. This is a step-up game for the Cardinals and it's also an off-surface for them. While I think the Cardinals are improved and on the right track under Satterfield, I don't see them staying within a touchdown of highly motivated Florida State.