This is a major flat spot for the Broncos after three straight wins beating the Chargers, Steelers and Bengals. It's their second consecutive road game and they just lost their best wide receiver, Emmanuel Sanders.

The 49ers usually play hard every week for Kyle Shanahan. The 49ers can move the ball - averaging 393.2 yards per game during their last four games - and they give up the 12th-fewest yards in the NFL.

Denver isn't good despite its recent hot streak. The Broncos were outgained by an average of 107.6 yards in their past three games.