South Alabama is giving up over 468 total yards on the road this season and they are only averaging 23 points per game. Louisiana is at home and they play much better there putting up 43 points of offense on average. They have the better defense and the Jaguars will struggle to move the ball. Louisiana is 6-2 ATS versus good teams who are outscoring opponents by 10 plus points per game on the season.

Best bet: lay the points with Louisiana.