Cincinnati is off a bye week so Burrow has had extra time to heal and the Bengals are 3-1 SU and 3-1 ATS off a bye in the last three seasons. They are off their win against Seattle, they have won three of their last four games, and are on the road in San Francisco. Burrow has played this team close in the past and with the amount of points they are getting, the value lies with the Bengals as the opening line was originally +1.5. The 49's are battling fresh injuries with McCaffrey, Samuel and Williams, so this is an advantage to the Bengals if one or all don't play. This will be a lower scoring game and the Bengals should cover the spread as this should come down to a field goal. The Bengals are also 2-0 ATS against NFC West opponents this season.

The Bengals as a road underdog of 3.5 to 9 points are 7-0 ATS in the last three seasons. Cincinnati after having won 3 out of their last 4 games are 10-3 ATS in the last three seasons. The Bengals after 2 or more consecutive wins against the spread are 15-4 ATS and 13-6 SU in the last three seasons. SF as a home favorite is 5-0 ATS this season. SF against AFC North division opponents is 1-1 ATS this season. Cincinnati is 3-1 against the spread versus SF in their last four games played in San Francisco.

Best bet: take the points with Cincinnati.