NFC West rivals meet up on Thanksgiving when first-place San Francisco takes on second-place Seattle. The 49ers are 7-3 this season and have won two in a row. The Seahawks are 6-4 and are coming off a tough loss to the Rams. The 49ers were in a three-game losing before winning their last two by a combined 61-17 score. Their offense is putting up 27.9 points which is fourth in the league. On the defensive side, they rank fifth in the league, allowing only 302.8 total yards per game. The Seahawks are limping into this game having dropped two of their last three games, scoring a combined 48 points. They have averaged 21.6 points per game this season, which ranks 16th in the NFL. On the defensive side, they are giving up 21.8 points and 345.6 total yards per game. The Niners are 3-0 SU and ATS in the last three meetings. Last season, San Francisco won by an average of 13 points in those games. Seattle is bagged up right now with their quarterback not being 100%, Kenneth Walker is out for this game and their tackles are banged up. The 49ers are not injury-free as both starting guards are questionable. The 49ers are better on both sides of the ball and with Seattle's injuries I feel they will struggle in this one.

Play on San Francisco. This is a 4% play.