Saints on their home turf should come out strong with Kamara and Murray, the Saints have the 1-2 punch that the Chargers' previous opponents have lacked. New Orleans is a complete offense, which means you can't scheme just to stop the run as Brees will throw on you. If you go six or seven defensive backs, Kamara and Murray will grind out yards and make life difficult. New Orleans has shown that they are committed to the run, especially with Thomas missing games of late. Look for the Saints to get a double-digit win here on MNF.