Cleveland at San Francisco 8:15 ET
49ers (-) over Browns- The past three seasons these two clubs have been the NFL's biggest losers and now they both are full of optimism while the rest of the league looks at them with skepticism. San Francisco is 3-0 and have had an extra week to prepare after taking down the Steelers 24-20 two weeks ago. Cleveland at 2-2 is off of a 40-25 win at Baltimore but there are internal struggles that play out on the field at time. The Browns huge ego's take another hit tonight. Take SAN FRANCISCO!