The current Orioles lineup has a .333 batting average and .3690 On-base percentage against Howard. On the other side, Charlie Culberson, Corey Seager, and Marcus Semien are a combined 10 for 20 (.500) with two home runs off of Jordan Lyles lifetime. Lyles has a 6.12 ERA on the road this season in 12 games, and Spencer Howard has a career 6.64 ERA in 33 career games. I like the over.