The Jacksonville Jaguars return home from two weeks across the pond and off an upset win over the Bills. The travel could become an issue for Jacksonville against a Colts team that has won three of its last four games outright. Gardner Minshew will quarterback Indianapolis, but I'm not sure he's that much of a downgrade from injured Anthony Richardson.

Over the last three seasons, the Colts are 14-10 ATS as an underdog while the Jags are 3-7 ATS as favorites (0-4 ATS as favorites of 3.5 to 7 points).

4* PLAY ON INDIANAPOLIS COLTS.