The Colts have a new QB in Matt Ryan, but the veteran has tons of experience and plenty of weapons around him. He'll settle in just fine and Jonathan Taylor is one of the top running backs in the league. The Texans are in rebuild mode, and they are inexperienced on both sides of the ball, but on defense in particular. The Colts to win seems like a no-brainer, but I'm not ready to lay this many points on the road and I like the over a lot better.

10* PLAY ON OVER.