The Arizona Cardinals are coming off a disappointing 20-17 loss to the New England Patriots. QB Kyler Murray did not look himself, and this week Murray (right shoulder) was limited in practice but is expected to play. The Cardinals have now lost three of their last four and they would need a fully healthy Murray to have any chance of moving the ball effectively against this elite Rams defense. The Rams took a last-second 23-20 home defeat to the San Francisco 49ers last Sunday, but they had won back-to-back outings prior to that game.

Rams are 6-1-1 ATS in their last 8 games following a straight up loss. Rams are 5-1 ATS vs. a team with a winning record. Rams are 11-5 ATS in their last 16 road games.

8* play on Los Angeles Rams.