These two teams have opened the season in completely different ways with the Arizona Cardinals 2-0 SU and ATS while the Detroit Lions are 0-2 SU and ATS.

Does that mean that the Lions are due to win at least ATS in Week 3? I don't think so.

Detroit's defense has been one of the worst in the league for the first two weeks giving up 425.5 yards per game (28th), and here they'll face an Arizona offense that has not skipped a beat ranking 6th in the NFL with 421 yards of offense per game.

Of particular interest is Detroit's struggle to defend the run giving up a league-worst 204 rushing yards per game while Arizona has been extremely efficient moving the rock on the ground.

Lions are 2-8 ATS in their last 10 games as an underdog and 0-6 ATS in their last 6 road games. Cardinals are 5-0 ATS vs. a team with a losing record.

10* play on Arizona Cardinals.