The San Francisco Giants came out on top Tuesday night as Mac Williamson's 423-foot homer in the sixth inning earned them a 4-3 victory. I think we'll see another low-scoring affair here on Wednesday, but with the Nats getting revenge this time.

Washington hands the ball to Max Scherzer (4-1, 1.36 ERA). He is just 3-4 with a 4.17 ERA in eight career starts against San Francisco, but this looks like a good time to improve on those numbers. Scherzer has been exceptional so far this season, allowing just 18 hits while striking out 47 in 33 innings.

The Giants turn to Jeff Samardzija (1-0, 0.00 ERA) who injured a pectoral muscle during spring training on March 21 and made his season debut as late as last Friday. He held the Halos scoreless over five innings but struggled somewhat with his control, issuing four walks, and might need another couple of games until he's at his best. Samardzija is 2-7 with a 4.07 ERA in 16 career appearances (nine starts) against the Nationals.

The Nats will be desperate for a win here after four straight defeats and sitting on a disappointing 10-14 record for the year.

8* play on Washington Nationals.