This is a 10* on OVER

Because of Covid, the 49ers have lost their home field advantage. This game is being played in Arizona (Cardinals stadium) as will next week’s “home game” vs. Washington. That’s a pretty significant disadvantage for the stretch run, although the Niners did just go on the road and beat a very good Rams team last week. Buffalo has already played once here in Arizona and that’s a game they’d like to forget as they lost on the infamous “Hail Murray.” If you recall, that was a high scoring game (32-30) as are most Bills games with the average number of total points scored being 52.8. That’s noticeably higher than the total set for tonight. The 49ers average 27.2 points/game at home, which is up from what they are averaging on the road. A key for them last week was that WR Deebo Samuel, who leads the league in yards after catch, returned to the lineup. The Over is 7-3-1 for the Bills this season including 7-0-1 when they are off a win. (They put up 27 in beating the Chargers last Sunday). Play on OVER

AAA