Taking SAN FRANCISCO here. 49ers laid an egg coming out of their bye last week. Not going to take anything away from the Panthers. They are playing as good as any team in the league right now. They might not be as flashy on offense as these Saints, but the defense is fierce. This is going to be like going from pounding steel to cotton. Saints defense has been reborn under Rob Ryan. But I think they might be a little flat coming off that beating of his old club. New Orleans 17-1 ATS last home last 18 with HC Sean Payton patrolling the sidelines. The fact is that San Fran knows how to beat N'awlens. They did it last year right here by 10 points. They did in the playoffs in January. Make it 3 straight for the reigning NFC Champs. 8* Sure Shot SAN FRANCISCO 49ers