Taking SAN FRAN here. I still like this even though Indy is adding Trent Richardson to the fold. Maybe the line drops a little for us. Either way, I do not think it makes a difference. 49ers were bitch-slapped on national tv last Sunday night. Colts walking into a hornets nest here. SF will be out for blood and will want to redeem themselves. SF 16-6-1 ATS last 23 at home. Luck gets to see his old coach. I am pretty sure Harbaugh knows what this kid likes to do on the field. And let's be honest here. SF opened against GB and Seattle. Two pretty good teams that have Super Bowl goals. Now they face Indy, who I thought last year over-achieved, and is playing exactly how I thought they would this year. Which is average to below average on defense. SF by 20 here! 8* Sure-Shot SF 49ers