Bet against Sean McDermott and his Bills during preseason at your own peril. The Bills are 9-1 in their last 10 preseason games. 

Yet the Colts are road favorites. That's way too much respect just because the Colts have announced that rookie QB Anthony Richardson will start. 
Richardson is as raw as they come. 

Josh Allen is not likely to play. But I like Buffalo's backup QB's - Kyle Allen and Matt Barkley - more than Richardson. Allen and Barkley are veterans who can produce against reserve defenders in a vanilla scheme.