The Saints got off to a fast start this year, but injuries have ravaged this team. The latest to fall is top WR Chris Olave, who has been ruled out from this game. Denver has the defense that can shut this anemic offense down, while their own offense will take aim at a struggling defense that has allowed 34.3 ppg over its last three games. Denver has already beaten the Jets and Bucs on the road, and they will do the same here with the Saints. Look for Denver to win this one.