The Jaguars are an 0-2 team that falls into the betting angles for teams in this situation; they go 36-20 against the spread in Week 3 for 65.1% cover rate. The Jags have a competent quarterback in Lawrence who should be competitive in this game and move the chains as they can run against this Bills defense. The Jags are still +0.2 in yards per play margin. They really should have won that Miami game in Week 1 as they were the better team, but allowed Miami to hold them to no points in the second half. Their defense should keep them in this game to at least cover the spread. Trevor Lawrence is 4-3 straight up and 5-2 against the spread, against the AFC North. Buffalo is also experiencing injuries at the linebacker position and in its secondary and this is also a look ahead spot for Buffalo who has Baltimore on deck next week and even with the extra rest, this should be a flat spot for Buffalo. Jacksonville is 4-2 against the spread in their last 6 games against Buffalo. Buffalo is 4-9 against the spread as the favorite. The Bills are 1-4 against the spread in their last 5 games against an opponent in the AFC South division.

Best bet: take the points with Jacksonville.