Detroit comes into this game off a bad loss at home to Tampa Bay and will want to regroup and get back to business against Arizona. The Lions have won the last two of three games in Arizona and the last four overall. The Lions have a good run defense and the Cardinals will struggle to put up points as Detroit should control the pace of the game as well. Arizona is just 3-5 against the spread after 1 or more consecutive wins, and after beating the spread by more than 28 points in their previous game; is a good fade spot for the Cardinals. Teams in this situation in the league don't cover in their next game and that happens about 81.8% of the time according to NFL betting angles. The Lions after a two game home stand, are 5-0 against the spread on the road in that situation. Detroit is also 10-3 against the spread on the road against conference opponents. The Cardinals are 0-2 against the spread against NFC North division opponents. Detroit should be much more motivated than the Cardinals in this game.

Best bet: lay the points with Detroit.