San Francisco enters this game 10-3 on the season and have won 5 games in a row. San Francisco won all 5 games by at least 12 points and their last 8 wins were by at least 12 points.

Arizona is 3-10 on the season and while they have played better since getting Kyler Murray back at QB they have not faced a team like San Francisco during that stretch.

San Francisco won 35-16 in the first game between the teams this season and it should be a similar result in this game.

Pick: San Francisco 49ers -11.5