Louisville needs a big win and the come no bigger in the ACC than No. 11 Clemson. Louisville is 5-3 overall and 3-2 in the ACC. The Tigers are 6-1 overall and 5-0 in the ACC. They have won six in a row and are coming off a bye. Louisville QB Tyler Shough ranks third in the ACC and ninth in the country with 2,348 passing yards and is tied for fourth in the nation with 20 TD passes. The offense puts up 36.6 points per game. On the defensive side, they are giving up 24.6 points per game this season. Clemson has won 5 straight in the ACC by an average of 29.5 points per game, Clemson’s offense is fourth in the country in scoring at 42-points a game.
On the defensive side, they are giving up 23 points a game. Clemson has dominated Louisville, winning all eight games and going 6-2 ATS. Clemson’s offense is loaded with weapons and should find the endzone against the Cardinals defense. Clemson is 6-0 ATS in their last six against Louisville and 4-2 ATS over their last six games. Louisville is 0-5 ATS in their last five games. I like Clemson to roll in this one.

Play on Clemson. This is a 5% play.