The Buffalo Bills come into this game having won four of their last five games and three of their last five on the road. The offense is led by Josh Allen with 3,028 passing yards, to go with 22 touchdowns and eight interceptions. He has hooked up with Stefon Diggs and Cole Beasley for a combined 1,612 receiving yards and seven touchdowns. As a team, they rush for 104.4 yards a game and are led by Devin Singletary with 483 yards and one touchdown. On the defensive side of the ball, they are giving up 25.6 points and 373.1 yards a game.

The San Francisco 49ers need a win having lost four of their last five home games. The offense is led by Nick Mullens with 1,642 passing yards, to go with six touchdowns and seven interceptions. He has teamed up with George Kittle and Brandon Aiyuk for a combined 920 receiving yards and five touchdowns. As a team, they rush for 112.3 yards a game and are led by Raheem Mostert with 346 yards and two touchdowns. On the defensive side of the ball, they are giving up 23.1 points and 315.2 yards a game.

The Buffalo Bills just continue to win, they are not pretty wins but wins nonetheless. The San Francisco 49ers probably played their best game last week in beating the rams on the road. The Niners defense has consistently shown up this year but the offense has struggled and has been hampered with injuries. The Bills have been the better and more consistent team this season.

PLay on the Buffalo Bills.